Sterol carrier protein-2: New roles in regulating lipid rafts and signaling
نویسندگان
چکیده
منابع مشابه
Role for lipid rafts in regulating interleukin-2 receptor signaling.
Lipid rafts are plasma membrane microdomains characterized by a unique lipid environment enriched in gangliosides and cholesterol, leading to their insolubility in nonionic detergents. Many receptors are constitutively or inducibly localized in lipid rafts, which have been shown to function as platforms coordinating the induction of signaling pathways. In this report, the first evidence is prov...
متن کاملSterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice.
BACKGROUND & AIMS Sterol carrier protein 2 (SCP-2) enhances sterol cycling and facilitates cholesterol translocation between intracellular organelles and plasma membrane in cultured cells, including hepatocytes. We examined the role of SCP-2 in hepatic cholesterol and lipid trafficking through the sinusoidal and canalicular secretory pathways of the liver in vivo. METHODS Recombinant adenovir...
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The biosynthesis and intracellular localization of nonspecific lipid transfer protein (nsLTP) in control human subjects and in patients with peroxisome-deficient disorders were investigated. The molecular mass of human nsLTP was indistinguishable from that of rat nsLTP (13 kDa) by immunoblot analysis. Intracellular localization was identical with that of catalase, a marker enzyme of peroxisomal...
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Through evolution, most of the living species have acquired a time keeping system to anticipate daily changes caused by the rotation of the Earth. In all of the systems this pacemaker is based on a molecular transcriptional/translational negative feedback loop able to generate rhythmic gene expression with a period close to 24 hours. Recent evidences suggest that post-transcriptional regulation...
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The traditional model of the plasma membrane as a homogeneous fluid lipid bilayer has been extended in recent years, as it has become clear that the plasma membrane consists of thousands of different lipids and is a much more complex structure than previously thought. Ceramide, cholesterol, and phophatidic acid are major membrane lipids, and most of them are modified with glucose to generate gl...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
سال: 2007
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2007.04.005